Immunopotentiating activity of abrin, a lectin from Abrus precatorius Linn.
نویسندگان
چکیده
A non-toxic dose of abrin, (1.25 microg/kg body wt) consecutively for five days in normal mice stimulated specific humoral responses. A noticeable increase was observed in total leucocyte count, lymphocytosis, weights of spleen and thymus, circulating antibody titre, antibody forming cells, bone marrow cellularity and alpha-esterase positive bone marrow cells. The results suggest that abrin can potentiate the humoral immune response of the host.
منابع مشابه
Effect of Shodhana on the Toxicity of Abrus Precatorius
Seeds of Gunja (Abrus precatorius Linn) are reported to be poisonous due to the presence of a toxic protein 'abrin and an alkaloid hypaphorine. Te seeds after subjecting to the process of shodhana, find use in a number of Ayurvedic preparations. HPLC studies revealed that the process of shodhana resulted in depletion of more toxic alkaloid hypaphorine and protein abrin.
متن کاملRegulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin
The role of abrin, a toxic lectin isolated from seeds of Abrus precatorius Linn in inducing apoptosis in murine Dalton's Lymphoma Ascites (DLA) cells was evaluated. Abrin when incubated at the concentration of 10 ng per million DLA cells could bring about cell death as typical morphological changes with apoptosis. However, necrotic cell death dominated when a higher dose of abrin was used. DNA ...
متن کاملImmunomodulatory Activity of the Aqueous Extract of Seeds of Abrus precatorius Linn (Jequirity) in Mice
Background: Various compounds of plant origin have been widely investigated since ancient times for their possible immunomodulatory properties as well as for the treatment of a wide range of diseases. Objective: To study the immunomodulatory functions of the aqueous extract of the seeds of Abrus precatorius commonly known as Indian liquorice (Fabaceae), a medicinal plant native to central India...
متن کاملAntitumour effect of abrin on transplanted tumours in mice.
Abrin, a galactose specific lectin was purified using sepharose 4B affinity column from seeds of Abrus precatorius. It exhibited antitumour activity in mice when used at a sublethal dose of 7.5 micrograms/kg every alternate day for 10 days. Both intralesional and intraperiloneal (i.p.) administration of abrin was effective in reducing solid tumour mass development induced by Dalton's Lymphoma A...
متن کاملPreliminary crystallographic data for a new crystalline form of abrin.
A new crystalline form of abrin has been obtained from the most toxic constituent of the seed extract of Abrus precatorius. An x-ray diffraction study shows that the toxin crystallizes in a monoclinic unit cell of probable symmetry P21 and parameters (I = 113 A, b = 72 A, c = 71 A, and /3 = 103”. The asymmetric unit contains 2 protein molecules of molecular weight 63,800 and has a solvent conte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 40 8 شماره
صفحات -
تاریخ انتشار 2002